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Expression of the CerS2 encoding gene in humans is the highest of all the CerS genes in human pancreatic -cells

Thus, enhanced ROS production after SARS-CoV-2 infection will elicit long-term deleterious effects on endothelial cells, including decreased NO bioavailability and flow-mediated vasodilation ( In summary, the pathomechanisms of acute COVID-19 infection in the CV system include direct viral toxicity, intracellular viral entry via ACE2 and glycocalyx modulation, alteration of ACE2 signaling cascade towards the activation of harmful Ang II/AT1R axis, activation of pro-inflammatory proteins and deregulation of the immune system, hyper-inflammatory milieu and cytokine storm formation, hyper-coagulopathy development, ED and damage (Figure 2), and cardiac fibrosis and cardiac remodeling (114)

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Identification of hub proteins The Network analyzer and cytohubba plugins were used to calculate the Degree and Betweenness Centrality (BC) scores of the PPI networks

313 StuhlmannT.Planells-CasesR.JentschT

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